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KMID : 0376119790060010075
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Medical Journal of the Red Cross Hospital
1979 Volume.6 No. 1 p.75 ~ p.80
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Clinical Study of Hydroxyzine as a Premedicant
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최미란/Choi, Mi Ran
김노식/김용조/이지수/이동기/Kim, No Sik/Kim, Yong Jo/Lee, Chi Su/Lee, Dong Ki
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Abstract
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Sedative and antiemetic effect of Hydroxyzine as a premedicar,4 were studied and results were compared with a placebo and Talwin. Two hundred and forty patients were evaluated. These patients were divided into 6 groups. There were forty patients in each group.
Group 1: Hydroxyzine 50mg.
Group 2: Hydroxyzine 100mg.
Group 3: Placebo.
Group 4: Talwin 20mg.
Group 5: Hydroxyzine 50mg plus. Talwin 20mg.
Group 6: Hydroxyzine 100mg plus Talwin 20mg.
The results were as follows;
1) Satisfactory sedation was obtained in 75% with group 1. in 92.5% with group 2, in 30% with group 3$ in 40% with group 4, in 82.5% with group 5, and in 97.5% with group 6. Better results were obtained with Hydroxyzine plus Talwin group than Hydrsxyzine only.
2) The incidence of postoperative nausea and vomiting in recovery room, 7.5% with group 1, 7.5910 with group 3, 20% with group 4, 5% with group 5. There was no case of nausea and vomiting in group 2 and-group 6. We obtained a significant difference in antiemetic effect between. Talwin only and the Talwin plus Hydroxyzine group.
3) There was no adverse change on- vital signs in all cases.
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